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KMID : 0603520040090020098
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Journal of Korean Association of Cancer Prevention
2004 Volume.9 No. 2 p.98 ~ p.103
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In Vitro Anticancer Effect of Active Compounds from Chinese Cabbage Kimchi
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Cho Eun-Ju
Choi Jae-Sue
Kim So-Hee
Park Kun-Young
Lee Sook-Hee
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Abstract
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The isolation and further fractionation for active compounds with anticancer activity from dichloromethane fraction of Chinese cabbage kimchi were carried out, and β- sitosterol and ergost-5-en-3.beta-ol (linoleic acid derivative) were identified as major compounds from GC-MS, EI-MS spectrum, 1H-NMR and 13C-NMR spectrum. The active compounds inhibited not only the survival of human caner cells, AGS gastric adenocarcinoma cell, HT-29 colon adenocarcinoma cell, HL-60 promyelocytic leukemia cell and MG-63 osteosarcoma cell, but also the synthesis of DNA within AGS cell. In particular, β-sitosterol showed the stronger in vitro anticancer activity than linoleic acid derivative. The present study suggests that anticancer effect of Chinese cabbage kimchi would be attributed to the active compounds, β-sitosterol and linoleic acid derivative.
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KEYWORD
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Kimchi, Anticancer effect, Cancer cell, β-sitosterol, Linoleic acid
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